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Anyone familiar with HPLC/Acetonitrile Solvent Removal?

Anyone familiar with HPLC/Acetonitrile Solvent Removal?

if you put the heating bath of your rotavap to 40°C, Acetonitrile will start evaporating @ approx. 90 mbar; if the pressure decreases to about 40 mbar, the AcN is gone.

Drying of Problematic Purification Samples by .

Drying of Problematic Purification Samples by .

Jun 13, 2011 · 2) Acetonitrile in the cold trap will spoil the vacuum, making lyophilization of the water almost impossible. 3) This slow process is incompatible with the reduced process times strived for. The centrifugal evaporator rapidly dries many different samples in parallel, without bumping.

The Rotary Evaporator

The Rotary Evaporator

The Rotary Evaporator It is commonly taught in General Chemistry classes that the vapor pressure of a liquid or solid varies directly with temperature, i.e., the higher the temperature of a substance, the higher its vapor pressure. When a liquid is heated it begins to boil as the liquid turns to vapor forming

METHOD FOR THE PURIFICATION OF MALONONITRILE BY THE .

METHOD FOR THE PURIFICATION OF MALONONITRILE BY THE .

Oct 26, 1971 · The treated material was allowed to stand 30 minutes and then distilled up to 120° C. (bath temperature) and at 5 mm. pressure on a rotary evaporator. 48 parts remained as residue. The distillate (155 parts) analyzed 36.2 wt. percent acetonitrile, 63.0 wt. percent malononitrile and 0.8 wt. percent fumaronitrile and malononitrile.

Isolation and purification of fumonisin B1 and B2 from .

Isolation and purification of fumonisin B1 and B2 from .

The mycotoxins were extracted from rice culture material (RCM) with acetonitrile-water (1:1), filtered, and the acetonitrile removed on a rotary evaporator. Preparative reverse phase liquid chromatography (LC) was used to isolate and partially purify FB1 and FB2 from the extract. The extract was applied to a C18 reverse phase cartridge.

Rotary Evaporation to Remove Solvent | Protocol

Rotary Evaporation to Remove Solvent | Protocol

Rotary evaporation is a technique commonly used in organic chemistry to remove a volatile solvent from a non-volatile compound of interest. Invented by Lyman C. Craig in 1950 the rotary evaporator, or rotovap, gently removes solvents from compounds using heat combined with reduced pressure to evaporate, dry, and purify samples for further downstream use.

5.5: Rotary Evaporation - Chemistry LibreTexts

5.5: Rotary Evaporation - Chemistry LibreTexts

Jun 23, 2019 · Contributors; The preferred method for solvent removal in the laboratory is by use of a rotary evaporator (also known as a "rotovap"). A rotary evaporator is essentially a reduced pressure distillation: a solution in a round bottomed flask is placed in the water bath of the apparatus, and rotated while the system is partially evacuated (by a water aspirator or vacuum pump).

Heidolph : Owner manual

Heidolph : Owner manual

Set-up and Start-up Set-up and Start-up 1 2 1 Figure 4-14: Evaporator flask inclination / immersion depth 1. Grasp the condenser with the left hand. 2. Unlock the locking device (1) at the lift column toward the right by applying pressure with your right hand. 3. Set the evaporator flask inclination by carefully swinging the condenser. 4.

Medicinal Chemistry and Product Purification

Medicinal Chemistry and Product Purification

Removal of 360 ml of 1:1 Acetonitrile:Water from 150 mm . remove solvent using a rotary evaporator, there is now a demand for . as you lower the surrounding pressure thus less heating is required to give complete evaporation.The rapid rotation of the centrifuge

Vacuum evaporation - Martin Christ Gefriertrocknungsanlagen

Vacuum evaporation - Martin Christ Gefriertrocknungsanlagen

Distillation systems and rotary evaporators use high temperatures for evaporation and operate at nearly atmospheric pressure or vacuum levels down to approximately 100 mbar. Freeze drying systems operate at very low temperatures and high vacuum down to less than 0.01 mbar.

Vacuum distillation - Wikipedia

Vacuum distillation - Wikipedia

Vacuum distillation is distillation performed under reduced pressure, which allows the purification of compounds not readily distilled at ambient pressures or simply to save time or energy. This technique separates compounds based on differences in boiling points. This technique is used when the boiling point of the desired compound is difficult to achieve or will cause the compound to decompose.

Solved: A Rotary Evaporator (or

Solved: A Rotary Evaporator (or "rotavap") Is Often Used I .

A rotary evaporator (or "rotavap") is often used in chemical laboratories to vaporize solvents at temperatures below the normal boiling point. Does the vaporization of acetonitrile at its adjusted boiling point under reduced pressure require a different amount of heat than the vaporization at its normal boiling point under normal pressure? Explain.

METHOD FOR THE PURIFICATION OF MALONONITRILE BY THE .

METHOD FOR THE PURIFICATION OF MALONONITRILE BY THE .

Oct 26, 1971 · The treated material was allowed to stand 30 minutes and then distilled up to 120° C. (bath temperature) and at 5 mm. pressure on a rotary evaporator. 48 parts remained as residue. The distillate (155 parts) analyzed 36.2 wt. percent acetonitrile, 63.0 wt. percent malononitrile and 0.8 wt. percent fumaronitrile and malononitrile.

Isolation and purification of fumonisin B1 and B2 from .

Isolation and purification of fumonisin B1 and B2 from .

The mycotoxins were extracted from rice culture material (RCM) with acetonitrile-water (1:1), filtered, and the acetonitrile removed on a rotary evaporator. Preparative reverse phase liquid chromatography (LC) was used to isolate and partially purify FB1 and FB2 from the extract. The extract was applied to a C18 reverse phase cartridge.

Determination of residues of deltaméthrin in wheat and .

Determination of residues of deltaméthrin in wheat and .

evaporator at 40°C. The dry residue is dissolved with 10 ml of acetonitrile (or methanol or hexane). It is then ready to be analysed. Analytical method A suitable volume (20µl) of the extract was injected into the column and eluted with a mobile phase: acetonitrile - water (92:8) V/V at a flow rate of 0.85 ml/min.

How to Select a Vacuum Pump for Rotary Evaporation? - Lab .

How to Select a Vacuum Pump for Rotary Evaporation? - Lab .

Applying vacuum using a pump is either helpful or necessary in most rotovap applications as it reduces the pressure within the system. This lowers the boiling temperature of the solvent resulting in faster evaporation and safer rotary evaporator operation. When composing a rotary evaporator setup, not just any pump will be up to the task. You .

JKEM J-KEM DVR-200 Digital Vacuum Regulator

JKEM J-KEM DVR-200 Digital Vacuum Regulator

A pressure ramp feature evacuates equipment at a user defined rate to eliminate bumping due to solvent degassing or over-evacuation. The vacuum regulator is ideally suited for large volume distillations, rotary evaporators and vacuum chambers. Recover > 99% of solvent from rotary evaporators. Features. NO mercury; digital pressure entry .

Rotary Evaporator Only Information

Rotary Evaporator Only Information

• A solvent table, below, from a large rotary evaporator manufacturer, Buchi. . correlates to a relative applied pressure of 75 torr (99 mbar). The evaporator could be run at lower temperatures that correlate to the recommended temperatures of ethanol, but 710 needs slightly

Rotary evaporator - Wikipedia

Rotary evaporator - Wikipedia

Rotary evaporators are also used in molecular cooking for the preparation of distillates and extracts.. A simple rotary evaporator system was invented by Lyman C. Craig. It was first commercialized by the Swiss company Büchi in 1957. In research the most common form is the 1L bench-top unit, whereas large scale (e.g., 20L-50L) versions are used in pilot plants in commercial chemical operations.

Hexamethylene diisocyanate (HDI), 2,4‐ and 2,6‐Toluylene .

Hexamethylene diisocyanate (HDI), 2,4‐ and 2,6‐Toluylene .

The toluene is evaporated on a rotary evaporator to a volume of 3 mL, transferred into a 10 mL test tube and dried in a stream of nitrogen. The residue is taken up in 1.0 mL acetonitrile. The urea derivatives are eluted from the absorption tubes with 30 mL acetonitrile. The eluates are combined and concentrated on the rotary evaporator.

Purification of sulforaphane from Brassica oleracea seed .

Purification of sulforaphane from Brassica oleracea seed .

2.4. Preparative low-pressure column chromatography. The methanol phase containing compounds of interest was dried at 35 °C under vacuum in a rotary evaporator, and the residue was purified by preparative low-pressure column chromatography. A 500 mm × 18 mm glass tube was used as the preparative chromatography column.

Solvent Evaporator at Thomas Scientific

Solvent Evaporator at Thomas Scientific

Nitrogen blow down reduces the partial pressure directly over the liquid to speed evaporation and help remove the solvent as it evaporators. . hexane and acetonitrile. . Buchi. The rotary evaporator R-100 is a high-quality, entry level Rotavapor to meet the essential needs in .

Types of Solvent Evaporators - An Overview | BioChromato

Types of Solvent Evaporators - An Overview | BioChromato

Jul 30, 2018 · A rotary evaporator (rotovap) works by placing the sample under vacuum thereby lowering the boiling point of the solvent. Typically, a round bottom flask is used where it is lowered in a heated water bath. The flask is rotated to increase the surface area and provide an even transfer of heat.

Solvent Evaporator at Thomas Scientific

Solvent Evaporator at Thomas Scientific

Nitrogen blow down reduces the partial pressure directly over the liquid to speed evaporation and help remove the solvent as it evaporators. . hexane and acetonitrile. . Buchi. The rotary evaporator R-100 is a high-quality, entry level Rotavapor to meet the essential needs in .

Rotary evaporator - Wikipedia

Rotary evaporator - Wikipedia

Boiling Temperature vs Chamber Pressure for Common Solvents-40-30-20-10 0 10 20 30 40 50 60 0.10 1.00 10.00 100.00 1000.00 Pressure (mbar) Boiling temperature (deg C) DMSO DMF Water Toluene IPA Ethanol Ethyl acetate Methanol Acetonitrile TFA Hexane Chloroform THF DCM Diethyl ether

Heidolph : Owner manual

Heidolph : Owner manual

Set-up and Start-up Set-up and Start-up 1 2 1 Figure 4-14: Evaporator flask inclination / immersion depth 1. Grasp the condenser with the left hand. 2. Unlock the locking device (1) at the lift column toward the right by applying pressure with your right hand. 3. Set the evaporator flask inclination by carefully swinging the condenser. 4.

Water Evaporation | Products & Suppliers | Engineering360

Water Evaporation | Products & Suppliers | Engineering360

Description: A multiple-effect evaporator, as defined in chemical engineering, is an apparatus for efficiently using the heat from steam to evaporate water.In a multiple-effect evaporator, water is boiled in a sequence of vessels, each held at a lower pressure than the last.. Application: Chemical Processing, Food Processing, Pulp and Paper Processing

Rotary Evaporators | Fisher Scientific

Rotary Evaporators | Fisher Scientific

Rotary Evaporators; Rotary Evaporators 1 – 30 1132 . Interest Areas. Life Science; Chemicals; Chromatography; Industries; Fisherbrand; Outlet Corner; Events and Exhibitions. The Story of Science World; Activate Science; On-Site Exhibitions; Trade Shows; .

How to use a Rotary Evaporator

How to use a Rotary Evaporator

A typical rotary evaporator has a water bath that can be heated in either a metal container or crystallization dish. This keeps the solvent from freezing during the evaporation process. The solvent is removed under vacuum, is trapped by a condenser and is collected for easy reuse or disposal.

Reversed Phase HPLC - an overview | ScienceDirect Topics

Reversed Phase HPLC - an overview | ScienceDirect Topics

Briefly, the dichloromethane extract is evaporated to dryness in a rotary evaporator, redissolved in a mixture of methanol/water/hexane (1:30:50 v/v), and subjected to liquid partitioning. The aqueous phases are then cleaned up using an immunoaffinity column containing monoclonal antibodies against aflatoxin M 1.