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Buchiglas - Process equipment > 250 liter

Buchiglas - Process equipment > 250 liter

Process equipment and production scale reactor systems for pharmaceutical and chemical manufacturing. - Glass and glass lined chemical reactor systems pharma pilot plant and kilo lab, glass process equipment, nutsch filter, gas scrubber, batch reactor.

Cryogenic Reactor - Pharmaceutical Manufacturing Resource

Cryogenic Reactor - Pharmaceutical Manufacturing Resource

QVF Process Systems' cryogenic reactor package enables chemists to carry out pilot scale reactions under accurately controlled conditions at both low and elevated temperatures in one reactor. The reactor is fully independent, with an integrated heat/chill system requiring only electricity and nitrogen to operate.

Pilot plant - Wikipedia

Pilot plant - Wikipedia

Pfaudler glass lined steel pilot scale reactors are ideal for pilot or kilo scale tests of new processes in corrosive media for chemical and pharmaceutical. . You can count on Edlon's fluoropolymer technologies for the safe containment and processing of concentrated HF and HCl solutions.

Reactor engineering - Ekato

Reactor engineering - Ekato

On the other hand, the challenges with bio-reactors (e.g. fermenters) are often their large volumes as well as the easy-to-clean design of the components. Both reactor types usually have to fulfil several mixing tasks at the same time. The agitator must not only intensively homogenise the contents of the reactor but suspend solids and disperse gas.

Development and Scale up in API Manufacture (Part1)

Development and Scale up in API Manufacture (Part1)

Will cover synthetic aspects of pharmaceutical production processes. 4 . - SCALE-UP (Kilo Lab, Pilot plant trials) - Transfer to Manufacturing Parallel synthesis reactor block . Labetalol Manufacturing Process Mono-pot reaction in jacketed, glass-lined 10,000 L reactor.

Custom Skid - Pharmaceutical | Paul Mueller Company

Custom Skid - Pharmaceutical | Paul Mueller Company

Paul Mueller Company custom skids are tailor-made to meet the specific requirements of your pharmaceutical manufacturing system.These systems can incorporate all of the monitoring equipment and control devices for the system into a compact skid which is assembled, integrated into a single PLC system, and factory tested.

Continuous Pharmaceutical Manufacturing - Contract Pharma

Continuous Pharmaceutical Manufacturing - Contract Pharma

Having to scale up multiple times, from laboratory scale to pilot scale for clinical trials, and then up to the final commercial scale can be very time-consuming and costly. With a continuous process, the scale up becomes much easier, as the scaling factor is much smaller, and may not exist at all: the equipment that is used for the process .

The Synthesis of Active Pharmaceutical Ingredients (APIs .

The Synthesis of Active Pharmaceutical Ingredients (APIs .

The implementation of continuous flow processing as a key enabling technology has transformed the way we conduct chemistry and has expanded our synthetic capabilities. As a result many new preparative routes have been designed towards commercially relevant drug compounds achieving more efficient and .

Kilolab Reactors | Kilo Scale Glass Reactor | Reactor Systems

Kilolab Reactors | Kilo Scale Glass Reactor | Reactor Systems

Contact Kilolabs for high quality pilot plant reactor systems. Kilolabs will provide you with industry leading glass reactors and kilo scale reactors. Contact Kilolabs for high quality pilot plant reactor systems. . Our systems are rugged enough for the safe and consistent production of Active Pharmaceutical Ingredients (API's) or potent .

European Medicines Agency

European Medicines Agency

The role of pilot scale batches is to provide data predictive of the production scale product. It may be necessary to further develop and optimise the manufacturing process using pilot scale 1 In the case of veterinary medicinal products, the minimum pilot batch size .

Continuous Pharmaceutical Manufacturing - Contract Pharma

Continuous Pharmaceutical Manufacturing - Contract Pharma

Having to scale up multiple times, from laboratory scale to pilot scale for clinical trials, and then up to the final commercial scale can be very time-consuming and costly. With a continuous process, the scale up becomes much easier, as the scaling factor is much smaller, and may not exist at all: the equipment that is used for the process .

Process chemistry - Wikipedia

Process chemistry - Wikipedia

Process chemistry is the arm of pharmaceutical chemistry concerned with the development and optimization of a synthetic scheme and pilot plant procedure to manufacture compounds for the drug development phase. Process chemistry is distinguished from medicinal chemistry, which is the arm of pharmaceutical chemistry tasked with designing and synthesizing molecules on small scale in the .

Determining Minimum Batch Size | Pharmaceutical Technology

Determining Minimum Batch Size | Pharmaceutical Technology

FDA's Guidance for Industry: Immediate Release Solid Dosage Forms Scale Up and Post Approval Changes (2) outlines the maximum allowable batch size as 10 times the size of the pilot/bio batch. FDA's cGMP guidance 21 Code of Federal Regulations 210.3 (3) provides clarity on batch and lot definitions.

From Pilot Plant to Manufacturing: Effect of Scale‐Up on .

From Pilot Plant to Manufacturing: Effect of Scale‐Up on .

Mar 15, 2010 · This article provides an overview of scale‐up considerations involved as one moves from bench‐scale reaction calorimetry to larger scale pilot plant and production reactors. Pharmaceutical Sciences Encyclopedia: Drug Discovery, Development, and Manufacturing

Manufacturers of Customized Pharmaceutical Process Pilot .

Manufacturers of Customized Pharmaceutical Process Pilot .

Pharma Pilot Plant, Pharmaceutical Processing Equipment, Pharmaceutical Machinery manufacturer / supplier in China, offering Manufacturers of Customized Pharmaceutical Process Pilot and Large Scale Plant, Facial Cleanser/Face Wash (foaming, milky, cream, gel) Vacuum Mixer Mixing Machine, Hydraulic Lifting Dissolver Paint Mixer Making Machine for Interior&Exterior Wall Paint and so on.

Cambrex Invests  2.4M in API Capacity at NC Facility .

Cambrex Invests 2.4M in API Capacity at NC Facility .

May 17, 2017 · Cambrex invests to increase pilot scale API capacity at its High Point, NC facility. Cambrex Corporation, a manufacturer of small molecule innovator and generic active pharmaceutical ingredients (APIs), announced that it is to expand pilot plant capabilities at its High Point, NC facility with the installation of a fourth reactor suite.

Extrusion & Compounding Equipment | Thermo Fisher .

Extrusion & Compounding Equipment | Thermo Fisher .

Achieve reliable scale-up, reduced time to market, and controlled, continuous processing using Thermo Scientific compounders and extruders. Our twin-screw compounders offer flexible compounding configurations for small batches for either pilot scale production or low volume manufacturing and are well-suited for research and development in the polymer, pharmaceutical, bioscience, and .

Cryogenic Reactor - Pharmaceutical Manufacturing Resource

Cryogenic Reactor - Pharmaceutical Manufacturing Resource

QVF Process Systems' cryogenic reactor package enables chemists to carry out pilot scale reactions under accurately controlled conditions at both low and elevated temperatures in one reactor. The reactor is fully independent, with an integrated heat/chill system requiring only electricity and nitrogen to operate.

API ScaleUp Calculations - Pharma Engineering

API ScaleUp Calculations - Pharma Engineering

Applying the approach Suppose for example, we did a series of experiments with a 5.0 gal. batch in an 11.5 in.-dia. pilot reactor, which had two 5-in.-diameter, three-blade, pitched-blade turbines, and found that we could get good results with the mixer operating at 300 rpm.

SECRETS OF BATCH PROCESS SCALE-UP

SECRETS OF BATCH PROCESS SCALE-UP

engineers in the pharmaceutical and fine chemical industries with limited pilot plant experience, who wish to learn more about the potential pitfalls of process scale-up and ways to avoid them. Complimentary Literature As part of the registration fee of this course, each participant will receive a copy of The Pilot Plant Real Book – A

Pilot Plant Reactor | Pilot Reactor Modular | Pilot Scale .

Pilot Plant Reactor | Pilot Reactor Modular | Pilot Scale .

A proprietary catalytic technology involving an ion-exchange reaction was proven commercially successful with a batch reactor pilot plant by EPIC. The pilot plant allowed the chemical company client to successfully scale from lab-sized and demonstrate the feasibility of a full manufacturing .

Tanks - Pharmaceutical Manufacturing | Paul Mueller Company

Tanks - Pharmaceutical Manufacturing | Paul Mueller Company

From pure water solutions for distilled water to biotech processing tanks fully equipped with controls, Paul Mueller Company offers an array of custom tanks to meet your unique pharmaceutical needs. Our dedicated and specialized engineering team will work with you to identify the best pharmaceutical equipment solution for your final product that will meet your industry's sanitary requirements.

Kilolab Reactors | Kilo Scale Glass Reactor | Reactor Systems

Kilolab Reactors | Kilo Scale Glass Reactor | Reactor Systems

Contact Kilolabs for high quality pilot plant reactor systems. Kilolabs will provide you with industry leading glass reactors and kilo scale reactors. Contact Kilolabs for high quality pilot plant reactor systems. . Our systems are rugged enough for the safe and consistent production of Active Pharmaceutical Ingredients (API's) or potent .

Continuous flow processing in the pharma industry

Continuous flow processing in the pharma industry

The first applications of continuous processes in the pharmaceutical industry emerged only comparatively recently and the vast majority of production is still undertaken in batch reactors. Herein, we highlight some of the advantages that continuous flow processing offers for the synthesis of pharmaceuticals and fine chemicals.

The synthesis of active pharmaceutical ingredients (APIs .

The synthesis of active pharmaceutical ingredients (APIs .

Jul 17, 2015 · Introduction. The last 20 years have witnessed a true renaissance in the way synthetic chemistry is performed due to the implementation of various enabling technologies allowing the modern synthesis chemist to select from a range of tools and equipment to best perform a given transformation [1–6].The trend to question the suitability of classical laboratory glassware and to utilise more .

What are the differences between a full-scale, pilot-scale .

What are the differences between a full-scale, pilot-scale .

Pilot scale is proof of concept at a scaled up size for treating up to 50% of a total actual flow for the application. Usually these are on-site at the eventual place where full scale will be .

Scale-up - Ekato

Scale-up - Ekato

Lab and pilot test vessels are commonly in the size range of 5 to 100 liters, in some cases with large scale-up factors also larger than 1 m³. For speciality chemicals and formulated or cosmetic products, the target sizes of the production systems are 1–100 m³, while reactors for mass products and fermenters can reach the range of up to .

Pilot Plant Solutions & Equipment | Pilot Plant .

Pilot Plant Solutions & Equipment | Pilot Plant .

PILOT PLANTS. Bridging the gap between bench-scale chemistry and commercial manufacturing. When you're on the critical path to technology commercialization, you need to know that you have a team of experts on your side that you can trust and have complete confidence in to help you successfully bridge the gap between bench-scale chemistry and commercial manufacturing.

Manufacturers of Customized Pharmaceutical Process Pilot .

Manufacturers of Customized Pharmaceutical Process Pilot .

Pharma Pilot Plant, Pharmaceutical Processing Equipment, Pharmaceutical Machinery manufacturer / supplier in China, offering Manufacturers of Customized Pharmaceutical Process Pilot and Large Scale Plant, Facial Cleanser/Face Wash (foaming, milky, cream, gel) Vacuum Mixer Mixing Machine, Hydraulic Lifting Dissolver Paint Mixer Making Machine for Interior&Exterior Wall Paint and so on.

Reactor engineering - Ekato

Reactor engineering - Ekato

On the other hand, the challenges with bio-reactors (e.g. fermenters) are often their large volumes as well as the easy-to-clean design of the components. Both reactor types usually have to fulfil several mixing tasks at the same time. The agitator must not only intensively homogenise the contents of the reactor but suspend solids and disperse gas.