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Lab-on-a-chip: microfluidics in drug discovery | Nature .

Lab-on-a-chip: microfluidics in drug discovery | Nature .

The vast majority of microfluidic devices are, however, simple planar microchips fabricated by photolithography on substrates such as glass, silicon or polymers 11,12,13,14.

US20020164275A1 - Combinatorial chemistry reactor system .

US20020164275A1 - Combinatorial chemistry reactor system .

US20020164275A1 US10/116,861 US11686102A US2002164275A1 US 20020164275 A1 US20020164275 A1 US 20020164275A1 US 11686102 A US11686102 A US 11686102A US 2002164275 A1 US2002164275 A

Borosilicate Reactors - Adams & Chittenden Scientific .

Borosilicate Reactors - Adams & Chittenden Scientific .

standard and custom stirred glass bioreactors for fermentation and cell culture, with and without jackets; microbial fuel cell reactors and electrochemical cells; organ baths,chambers, and reactors for medicinal research; reaction vessels for materials research and combinatorial chemistry; and OEM glass reactors and replacements for complete .

Design and testing of a new type of DBD flow reactors for .

Design and testing of a new type of DBD flow reactors for .

Keywords: combinatorial surface technology, gradient surfaces, plasma-assisted deposition, plasma treatment, high throughput experimentation . 1. Introduction The present contribution reports on the design and testing of a new kind of reactors for plasma-assisted chemical vapor deposition PACVD) processes (DBD- or

The SynthArray Reactor System - Parallel Synthesis for .

The SynthArray Reactor System - Parallel Synthesis for .

Disposable glass reactors make it inexpensive to use; Available parts (like the tube holder) can be used separately; A report describing the SynthArray reactors was recently published in The Journal of Combinatorial Chemistry. Novel Array Reactors for Parallel Synthesis. Philip F. Hughes, Thomas H. Graham and Jose S. Mendoza. J. Comb.

Multi-reactor synthesizer and method for combinatorial .

Multi-reactor synthesizer and method for combinatorial .

Aug 11, 1998 · Solid phase combinatorial synthesis is carried out in a multi-reactor synthesizer comprising an array of separate reactor cells containing a solid reaction support medium. Subsets of reactor cells are interconnected with one another in a desired pattern, and, in a first reaction step, reagents are circulated through the subsets.

Combinatorial drug discovery in nanoliter droplets | PNAS

Combinatorial drug discovery in nanoliter droplets | PNAS

Jun 26, 2018 · The conventional single-agent approach to therapeutics is challenged by the redundancy and feedback in biological networks. The use of multiple drugs in combination might improve desired functional outcomes while reducing toxicity and overcoming drug resistance. However, the complexity and resources required to test many combinations have slowed discovery efforts.

Combinatorial drug discovery in nanoliter droplets | PNAS

Combinatorial drug discovery in nanoliter droplets | PNAS

Jun 26, 2018 · The conventional single-agent approach to therapeutics is challenged by the redundancy and feedback in biological networks. The use of multiple drugs in combination might improve desired functional outcomes while reducing toxicity and overcoming drug resistance. However, the complexity and resources required to test many combinations have slowed discovery efforts.

The Fast and the Curious: High-Throughput Experimentation .

The Fast and the Curious: High-Throughput Experimentation .

Combinatorial and high-throughput methods have revo-lutionized pharmaceutical research in the last decades.1–7 . systems were equipped with double-jacket glass reactors (in our case, up to 80 parallel 13-mL reactors or up to 20 parallel 75-mL reactors, or combinations of both) and

glass reactor, molecular distillation -

glass reactor, molecular distillation -

Henan Chengyitong Machinery Equipment Co., Ltd., Experts in Manufacturing and Exporting glass reactor, molecular distillation and 872 more Products. A Verified CN Gold Supplier on .

High Performance ontinuous &low hemistry Systems

High Performance ontinuous &low hemistry Systems

Glass static mixer reactor blocks The Uniqsis 2- and 3-channel borosilicate glass mixer block/chip reactor is de-signed for high throughput applications, fast mixing-dependent reactions and fast, highly exothermic reactions requiring temperature control. For heating and cooling, the mixer block can be mounted on the FlowSyn column

Readily Constructed Glass Piston Pump for Gas Recirculation

Readily Constructed Glass Piston Pump for Gas Recirculation

The recirculation of gases in a sealed reactor system is a broadly useful method in catalytic and electrocatalytic studies. It is especially relevant when a reactant gas reacts slowly with respect to residence time in a catalytic reaction zone and when mass transport control through the reaction zone is necessary. This need is well illustrated in the field of electrocatalytic N2 reduction .

Series 5500 High Pressure Compact Laboratory Reactors .

Series 5500 High Pressure Compact Laboratory Reactors .

Series 5500 High Pressure Compact Laboratory Reactors The Series 5500 reactors are based on the popular 4560 and 4590 line of Mini and Micro Reactors. A redesigned compact magnetic drive, stirrer motor, and aluminum block heater that also serves as the stand keep the size and costs down.

Titan 357 Combinatorial Library Synthesizer | AAPPTec

Titan 357 Combinatorial Library Synthesizer | AAPPTec

The reactor assembly of the Titan 357 Automated Split-and-Combine Combinatorial Peptide Synthesizer features a 500 mL reaction vessel that can be used to prepare larger quantities of a single peptide. Vortex mixing, nitrogen bubbling or a combination of both ensure complete mixing and optimum reactions. FEATURES Special Reactor Assembly

Continuous flow reactors for drug discovery - ScienceDirect

Continuous flow reactors for drug discovery - ScienceDirect

The micro reactor may be used to produce a combinatorial library of compounds, which may be separated by integrating the micro reactor with either a HPLC or capillary electrophoresis system, for example. The end of the separation column may be further integrated to a bioassay system such that each compound can be individually screened.

Multiparallel High-Pressure Reaction in a 384 Microplate

Multiparallel High-Pressure Reaction in a 384 Microplate

microplate reactor, combinatorial chemistry, laboratory automation, catalyst screening, high-pressure reactions . MultiChem, or glass can be used. The support frame and the perforated plate are made of the nonmagnetic Hastelloy C-22. The microplate will be sealed with the cap mat positioned

High Performance ontinuous &low hemistry Systems

High Performance ontinuous &low hemistry Systems

Glass static mixer reactor blocks The Uniqsis 2- and 3-channel borosilicate glass mixer block/chip reactor is de-signed for high throughput applications, fast mixing-dependent reactions and fast, highly exothermic reactions requiring temperature control. For heating and cooling, the mixer block can be mounted on the FlowSyn column

Microfluidic synthesis of fatty acid esters: Integration .

Microfluidic synthesis of fatty acid esters: Integration .

Integration of dynamic combinatorial chemistry and scale effect was designed to realize the efficient synthesis of bioactive compounds. . Glass chip reactors and mixers; High temperature tube reactor; Heated mixing tube reactor; . More kinds of fatty acid esters were detected in the fixed bed flow reactor compared with the results in the .

Microfluidic synthesis of fatty acid esters: Integration .

Microfluidic synthesis of fatty acid esters: Integration .

Integration of dynamic combinatorial chemistry and scale effect was designed to realize the efficient synthesis of bioactive compounds. . Glass chip reactors and mixers; High temperature tube reactor; Heated mixing tube reactor; . More kinds of fatty acid esters were detected in the fixed bed flow reactor compared with the results in the .

Techniques and Instrumentation for Combinatorial and High .

Techniques and Instrumentation for Combinatorial and High .

Jan 01, 2004 · Summary: Emerging from the field of biochemistry and pharmaceutical research, combinatorial and high‐throughput synthesis and screening methodologies are rapidly being adopted in polymer and materials research. Alternative solutions to cost intensive custom‐made synthetic robot systems have become commercially available and further accelerate this field of research not just in .

The Application of Micro Reactors for Chemical Synthesis .

The Application of Micro Reactors for Chemical Synthesis .

combinatorial library of pyrazoles within a glass micro reactor system operated using hydrodynamic control [11]. A T-shaped micro reactor was used to react seven 1,3-dicarbonyl compounds 1 sequentially with three hydrazine derivatives 2 to produce a 21-member library of pyrazoles3 (Scheme 1). 1 3 R O NH 2NHR 3 2 O R2 R 1 N N R R R R3 Scheme 1

Metal–organic framework - Wikipedia

Metal–organic framework - Wikipedia

Metal–organic frameworks (MOFs) are a class of compounds consisting of metal ions or clusters coordinated to organic ligands to form one-, two-, or three-dimensional structures. They are a subclass of coordination polymers, with the special feature that they are often porous.The organic ligands included are sometimes referred to as "struts", one example being 1,4-benzenedicarboxylic acid (BDC).

Lab Chemic Reactor Suppliers, Manufacturer, Distributor .

Lab Chemic Reactor Suppliers, Manufacturer, Distributor .

Alibaba offers 247 Lab Chemic Reactor Suppliers, and Lab Chemic Reactor Manufacturers, Distributors, Factories, Companies. There are 142 OEM, 143 ODM, 42 Self Patent. Find high quality Lab Chemic Reactor Suppliers on Alibaba.

The Application of Micro Reactors for Chemical Synthesis .

The Application of Micro Reactors for Chemical Synthesis .

combinatorial library of pyrazoles within a glass micro reactor system operated using hydrodynamic control [11]. A T-shaped micro reactor was used to react seven 1,3-dicarbonyl compounds 1 sequentially with three hydrazine derivatives 2 to produce a 21-member library of pyrazoles3 (Scheme 1). 1 3 R O NH 2NHR 3 2 O R2 R 1 N N R R R R3 Scheme 1

Precise Temperature Control for Flow Chemistry GSM Chip .

Precise Temperature Control for Flow Chemistry GSM Chip .

The Uniqsis range of chemically-resistant borosilicate glass chip reactor blocks can be used as static mixers to ensure effective mixing before a coil reactor or to perform fast exothermic experiments such as nitration's or bromination's where reaction times are often less than one minute.

Understanding Combinatorial Atomic Layer Deposition and .

Understanding Combinatorial Atomic Layer Deposition and .

Table 3.1 Operating conditions for fluidized bed reactor 20 Table 4.1 Summary of deposition conditions for combinatorial ALD, 40 two-component ALD and three-component ALD. Table 4.2 X-ray reflectivity modeling results 46 Table 4.3 Results of CVD-mode precursor depositions 48 Table 5.1 Deposition conditions for LPCVD reactor 58

Parallel combinatorial chemical synthesis using single .

Parallel combinatorial chemical synthesis using single .

For example, past achievements include the combinatorial preparation of six 2-aminothiazoles using a Hantzsch synthesis in a heated glass microreactor and the synthesis of a 7×3 library of pyrazoles using a Knorr reaction of 1,3-dicarbonyl compounds with hydrazines. 4 In each of these studies, the reactions were run in a sequential (time .

Automated Parallel Synthesis - ISYNTH from CHEMSPEED

Automated Parallel Synthesis - ISYNTH from CHEMSPEED

Easy-to-use disposable glass reactors / vials and / or reusable double-jacket reactors and / or microwave reactors for parallel synthesis. Reagent preparation (liquids and solids), multistep synthesis, work-up, purification, analysis and product transfer to storage. Ventilated, conditioned hood for e.g. sensitive, low-temperature chemistry.

Control and detection of chemical reactions in .

Control and detection of chemical reactions in .

Jul 26, 2006 · Recent years have seen considerable progress in the development of microfabricated systems for use in the chemical and biological sciences. Much development has been driven by .

A simple homemade reaction station for use in parallel .

A simple homemade reaction station for use in parallel .

May 19, 2006 · Glass reactors are connected by flexible 16-gauge metal needles to a central gas manifold equipped with an inlet/outlet for vacuum and inert gases. Reaction temperatures can be optimally varied from -78 ( composite function)C to 150 degrees C. . Combinatorial Peptide and Nonpeptide Libraries, VCH, Weinheim, 1996, pp. 303–326. Hoyle, W .